In basic, the security and also effectiveness of hydrochlorothiazide-irbesartan has been examined in over 700 patients. Negative effects linked with using hydrochlorothiazide-irbesartan have typically been transient and also mild. [Ref]
Cardiovascular negative effects connected with hydrochlorothiazide-irbesartan have actually been reported hardly ever as well as have happened at a rate much less compared to or equal to sugar pill. These have actually included breast pain, edema, lightheadedness, sinus arrhythmia, tachycardia, as well as cardiac arrhythmias (consisting of ventricular ectopy and also complete AV heart block). Arrhythmias in the lack of HCTZ-induced electrolyte disturbances have actually been stated seldom. Orthostatic hypotension has been stated seldom. Cardiovascular side effects connected with irbesartan consisting of flushing, hypertension, cardiac murmur, myocardial infarction, angina pectoris, arrhythmias, cardiorespiratory apprehension, and also hypertensive crisis have actually been reported in much less than 1 % of individuals in measured tests. Bradycardia has been reported in less compared to 1 % of patients in postmarketing encounter. [Ref]
Intestinal adverse effects connected with HCTZ have actually hardly ever included pancreatitis as well as intense cholecystitis. Bowel strictures have actually been reported. Intestinal negative side effects related to irbesartan have actually been stated one of the most often. Diarrhea (3 % vs. 2 % in inactive medicine) as well as dyspepsia (2 % vs. 1 % in placebo) have actually been reported. Stomach pain, nausea or vomiting, and also throwing up have actually been stated in 1 % or better among patients as well as at the very least as frequent or a lot more frequent in people getting inactive medicine. Constipation, gastroenteritis, flatulence, and abdominal distension have been reported in much less compared to 1 % of individuals in measured tests. Dry mouth, pyrosis, and also epigastralgia have actually been reported in less than 1 % of individuals in postmarketing experience. [Ref]
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